Malene Linderoth
Chromatography Scale-Up: Flow Rate, Linear Velocity & Column Diameter
A linear velocity of 150 cm/h can appear in a process specification at development scale ...
Mechanical Forces in Larger Chromatography Columns
How Mechanical Forces Change as Chromatography Column Diameter Increases Scaling a ...
When HETP Changes: A Structured Troubleshooting Approach
A chromatography column is packed, qualified, and put into service. The efficiency test ...
Why Wall Effects Occur in Packed Chromatography Columns
Wall effects in packed chromatography columns begin with something very simple: particles ...
At Larger Diameters, Wall Effects do not Disappear. They Change Role.
Scaling a chromatography column from development scale to production scale changes more ...
When Resin Settles Too Early During Packing Preparation
When the Issue Starts before Packing A column has been packed, the packing test has been ...
What the Pressure Equipment Directive Means for Chromatography Columns
A chromatography column is a pressure vessel. It has a defined maximum allowable ...
Why Chromatography Column Scale-Up Rarely Works the Way You Expect
Chromatography Column Scale-Up is not Just a Linear Process
How Platform Chromatography Changes as Purification Challenges Increase
Platform-based chromatography remains a widely used approach in downstream processing, ...